- Sedation in tablets is primarily caused by barbiturates, benzodiazepines, and alcohol.
- These substances induce sedation and hypnotic activity by affecting the brain’s sleep cycles, particularly by decreasing the total REM (Rapid Eye Movement) time and increasing the amount of NREM (Non-Rapid Eye Movement) sleep.
Role of Gamma-Aminobutyric Acid (GABA):
- The brain contains two types of pathways: one that activates and one that inhibits activities.
- The endogenous neurotransmitters of the inhibitory system include gamma-aminobutyric acid (GABA).
- Sedatives potentiate the action of GABA, which inhibits the brain pathways that keep a person awake, leading to sedation or sleep.
Dig Deeper: Know about hormones and Neurons impacting human health.
