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Nobel Prize in Chemistry for Computational Protein Design and Protein Structure Prediction

  • The 2024 Nobel Prize in Chemistry was awarded to David Baker for computational protein design and to Demis Hassabis and John Jumper for protein structure prediction.
  • The prize honours groundbreaking work in understanding the link between amino acid sequences and protein structures.
  • Computational Protein Design:
  • David Baker led a team that in 2003 designed new proteins using computational methods.
  • These methods have evolved to create “designer” proteins for specific applications.
  • His team’s work is described as enabling the construction of almost any type of protein.
  • AlphaFold2 for Prediction of Protein Structure:
  • Hassabis and Jumper developed AlphaFold 2, an AI model capable of predicting the structure of millions of proteins, surpassing the 1.7 lakh proteins previously mapped by human scientists.
  • Their work is noted for breaking new ground in 2020 by using AI to predict complex protein structures.
  • AlphaFold2 has been used by more than two million people from 190 countries. 

Dig Deeper: Read about the basic functions of Protein in Human cells and Body.

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